Daniel Wuttke wanted to solve aging since he was aware of this phenomena.
Already as a child he was curious and constantly asking why people are aging and have to die. He wanted become a scientist and dedicate his life to figure it out. He started a study in biochemistry in such he can learn both biology and chemistry. He also received math and physics training during his undergraduate studies. He finished up a BSc project on molecular cloning in which he established a method for coexpressing multiple genes from a single vector. Then he started an MSc and specialized into molecular medicine and cultured mouse and human stem cells in the laboratory. He even played with cellular reprogramming, the induction of pluripotency by introducing defined factors into somatic cells (iPS, i.e. reversing the developmental clock). He studied all the papers about iPS cells at this time. He wanted then do something like this for aging: Taking old cells, reprogram them and making them young again. Cells/organisms are basically just like computer/machines. In order to do this we need to find the right factors, therefore he started a PhD on the Genomics on Aging at the University of Liverpool, where he acquired training in statistics, bioinformatics and omics. In the meantime he taught himself very strictly Programming. He anticipated that it well be very important, or even of crucial importance, in the post-genomic era. It was always a child dream of him to create something like a universal computer program, something like an digital assistant.
Currently Daniel Wuttke (MPhil) works on «Functional Genomics of Aging and its Modulation by Diet» at the Integrative Genomics of Aging Group where he created GenDR, the first database on genes related to dietary restriction.
In Cambridge he supported the Strategies for Engineered Negligible Senescence (SENS) via organizational tasks and subsequently became a mentor ofthe SRF Eduction (formerly SENS Foundation Academic Initiative).
He initiated the Denigma project and belongs to the leadership of the International Longevity Alliance.
09/10 – 10/13 University of Liverpool (UK), School of Biological Sciences, Doctor of Philosophy
PhD project: Functional Genomics of Ageing and its Modulation by Diet
09/09 – 09/10 Un
iversity of Liverpool, School of Biological Sciences, Master of Philosophy
09/08 – 09/09 Ruhr University Bochum (Germany), Master of Science in Biochemistry, Main focus: Molecular Medicine
09/05 – 09/08 Ruhr University Bochum, Bachelor of Science in Biochemistry
BSc project: Expression of Ebony and EGFP from a 2A peptide construct in Schneider S2 cells
Practical skills: Chemistry, molecular cloning, cell culture, transfection/transduction, immunological methods
Special fields: Biogerontology, systems biology, signal transduction, gene regulation, metabolism, epigenetics, bioinformatics, stem and molecular cell biology, genetic engineering, knowledge engineering
Xia Y, Rudolf X, Wuttke D, Craft W, Shi Q, Ndega GMN, Singh L, Yu X, Bush JM, Bard M, Magalhães JP, Tang F. The accelerated late endosome-vacuole fusion is a key step in Osh6-triggered longevity. Traffic (submitted).
Fortney K, Wuttke D, Morgen E, Choi J, Ramesh N, Shytikov D, Schaum N, John AM, Goldberg B, Levine A, Litovchenko M, Narkeviciute A, Quist E, Vyas J, Rebo J, Betts-Lacroix J (2013) Longevity Variant Database: genetic variants implicated in human longevity. Nucleic Acid Research (submitted).
Craig T, Smelick C, Tacutu R, Wuttke D, Wood SH, Stanley H, Janssens G, Savitskaya E, Moskalev A, Arking R de Magalhães, JP (2013) The Digital Ageing Atlas: Integrating the diversity of age-related changes into a unified resource. Nature Biotechnology (submitted).
Debonneuil, E. Stambler, I (2013) Linking Researchers – Revolutionizing Aging Research with Tools and Collaboration h++.
Tacutu R, Craig T, Budovsky A, Wuttke D, Lehmann G, Taranukha D, Costa J, Fraifeld VE, de Magalhães JP (2013) Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing. Nucleic acids research 41: D1027-33.
Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing, A, Suhnel J, Wuttke D, Vera J (2012) Systems Biology and Bioinformatics in Aging Research: A Workshop Report. Rejuvenation Res.
Wuttke D, de Magalhães JP (2012) Osh6 links yeast vacuolar functions to lifespan extension and TOR. Cell cycle. (Georgetown, Tex.) 11: 2419.
Wuttke D, Connor R, Vora C, Craig T, Li Y, Wood S, Vasieva O, Shmookler Reis R, Tang F, de Magalhães JP (2012) Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. PLoS genetics 8: e1002834.
Johnson AA, Akman K, Calimport SR, Wuttke D, Stolzing A, de Magalhães JP (2012) The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation research 15: 483-94.
Plank M, Wuttke D, van Dam S, Clarke SA, de Magalhães JP (2012) A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms. Molecular BioSystems 8: 1339-49.
de Magalhães JP, Wuttke D, Wood SH, Plank M, Vora C (2012) Genome-environment interactions that modulate aging: powerful targets for drug discovery. Pharmacological reviews 64: 88-101.
Wuttke D, de Magalhães JP, (2011). Molecular Signatures to Decipher Ageing. Reproductive ageing: a basic clinical update, Book chapter.